Liveon Biolabs Toxicology
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Toxicology

At Liveon Biolabs, we understand the importance of toxicology data for regulatory approvals. Our expert toxicologists provide below toxicology studies as per OECD, US FDA, ISO and Schedule Y guidelines.

In Vivo Toxicology Studies

  • Maximum Tolerable Dose(MTD)
  • Dose Range Finding (DRF)
  • Acute Toxicity studies
  • Sub-acute Toxicity Studies (14 and 28 days)
  • Sub-Chronic and Chronic Toxicity Studies
  • Skin, Mucous Membrane and Eye Irritation Studies
  • Skin Sensitization Studies (GPMT)
  • Immunogenicity Studies
  • Local Lymph Node Assay (LLNA) by BrdU ELISA
  • Reproductive and Developmental Toxicology Studies
  • Carcinogenicity studies
  • Uterotrophic and Hershberger assays for endocrine disruption

Genetic Toxicology Studies

  • Bacterial Reverse Mutation Test (Ames test)
  • In vitro Mammalian Chromosome Aberration Test
  • In vitro Micronucleus Test
  • In vivo Mammalian Erythrocyte Micronucleus Test
  • In vivo Mammalian Bone Marrow Chromosome Aberration Test
  • Cell Gene Mutation

In Vitro Services

  • Cytotoxicity
  • MTT Assay

Alternative to Animals Models

  • In Vitro Skin Irritations/Corrosion
  • Hen’s Egg Test – Chorioallantoic Membrane (HET-CAM)
  • In Vitro Skin/Dermal absorption using Ex vivo skin models

Route of Administration

Liveon Biolabs has expertised in below routes of administrations for in vivo studies :

  • Oral (PO)
  • Intravenous (IV)
  • Intradermal(ID)
  • Intraperitoneal (IP)
  • Subcutaneous (SC)
  • Intramuscular (IM)
  • Topical
  • Ocular, Intraocular, Intravitreal and Intracorneal
  • Intratracheal
  • Sublingual in Rabbits