In-Vivo Models
In Vivo Pharmacology Models
Explore our diverse range of pharmacology models, covering central nervous system, respiratory system, gastrointestinal system, ulcer models, pain, inflammation, nephroprotection, ophthalmology, obesity, diabetes, and more.
Choose LiveonBiolabs as your trusted partner for toxicology and preclinical studies. Our team of experienced scientists and toxicologists is dedicated to guiding you through the complexities of safety evaluation and testing, ensuring precision, reliability, and utmost care. Together, we create a safer, more informed world through cutting-edge toxicology solutions.
- Pylorus Ligation
- Ethanol Induced
- Indomethacin Induced
- Acetic Acid Induced
- Histamine Induced
- Methylene Induced
- Stress Induced
- Dextran Sodium Sulphate Induced
- Oxazolone Induced
- Trinitrobenzene Sulphonic acid Induced
- OGTT, ITT & GSIS Assays
- Alloxan Induced
- Streptozotocin Induced
- Diet Induced Model
- Triton Induced Hyperlipidemia
- High Fat Diet Induced Obesity
- Subcutaneous tumor Models
- Solld Tumors Cell Lines: Ovarian, Lungs,Colon, Pancreas, Giloblastoma and Breast Cancer
- Hematological Tumor Cell Lines: AML, CML and Burkits’s Lymphoma
- Orthotopic Tumor Models
- Patient – Derived Xenografts (PDX) Models
- Skin/Thigh Infection
- Aerosol / Lung Infection
- Wound Healing
At Liveon Biolabs, we understand the importance of toxicology data for regulatory approvals. Our expert toxicologists provide below toxicology studies as per OECD, US FDA, ISO and Schedule Y guidelines.
In Vivo Toxicology Studies
- Maximum Tolerable Dose(MTD)
- Dose Range Finding (DRF)
- Acute Toxicity studies
- Sub-acute Toxicity Studies (14 and 28 days)
- Sub-Chronic and Chronic Toxicity Studies
- Skin, Mucous Membrane and Eye Irritation Studies
- Skin Sensitization Studies (GPMT)
- Immunogenicity Studies
- Local Lymph Node Assay (LLNA) by BrdU ELISA
- Reproductive and Developmental Toxicology Studies
- Carcinogenicity studies
- Uterotrophic and Hershberger assays for endocrine disruption
Genetic Toxicology Studies
- Bacterial Reverse Mutation Test (Ames test)
- In vitro Mammalian Chromosome Aberration Test
- In vitro Micronucleus Test
- In vivo Mammalian Erythrocyte Micronucleus Test
- In vivo Mammalian Bone Marrow Chromosome Aberration Test
- Cell Gene Mutation
In Vitro Services
- Cytotoxicity
- MTT Assay
Alternative to Animals Models
- In Vitro Skin Irritations/Corrosion
- Hen’s Egg Test – Chorioallantoic Membrane (HET-CAM)
- In Vitro Skin/Dermal absorption using Ex vivo skin models
Route of Administration
Liveon Biolabs has expertised in below routes of administrations for in vivo studies :
- Oral (PO)
- Intravenous (IV)
- Intradermal(ID)
- Intraperitoneal (IP)
- Subcutaneous (SC)
- Intramuscular (IM)
- Topical
- Ocular, Intraocular, Intravitreal and Intracorneal
- Intratracheal
- Sublingual in Rabbits
Liveon Biolabs has years of experience in providing Bioassays under Drug Testing Laboratory Services :
Bioassays
- Urofoliotropin (FSH), Menotropin (FSH), LH bioassays – IP, BP and USP
- Human Chorionic Gonadotropin (HCG) Bioassay – IP, BP and USP
- Erythropoietin bioassay – EP
- Insulin Biopotency Test (USP)
- Insulin Bioidentity Test (USP)
- Microbiology Screening
- Sterility Test
- Bacterial Endotoxin Test (Quantitative)
- Heparin Sodium and Enoxaparin Sodium IIa and Xa Activity
Liveon Biolabs understands your efforts towards developing beautiful cosmetic products to enhance the beauty of world population. At Liveon Biolabs, we prove your efficacy and safety claims using validated and globally accepted methods. We update ourself with latest advancements and we too respect the decision of ban on animal testing for cosmetics by many countries. Therefore, we strictly implement 3Rs.
Below are the tests we provide for cosmetics to prove safety and efficacy :
- Preservative Efficacy Test
- Antimicrobial Effectiveness Testing
- Pathogen detection and Endotoxin Testing
- Microbiology
- Skin Irritation/Corrosion
- In vitro Dermal Absorption
Liveon BioLabs Private Limited (LBPL) has rich experience, vast knowledge, advanced technologies and IT powered processes to conduct clinical studies. With strong local know-how and several years of international regulatory experience, LBPL is your right partner for conducting clinical research studies in India. Our expertise and leadership in Preclinical/Non-clinical testing studies over the years has been extended to offer wider range of clinical research services such as clinical end point studies, claim studies for cosmetics and consumer care products, BA/BE studies and clinical studies for complex neutraceuticals.
Services :
- Clinical trial management
- Project Management
- Clinical trial monitoring
- Study feasibility
- Patient recruitment
- Medical writing
Clinical Trial Management
LBPL optimizes study operations, saves costs and stays compliant for planning, conducting and monitoring your study.
- Manage the study start-up activities
- Ethics Committee coordination
- Faster patient recruitment
- Clinical trial supply management
- Documentation
- Leadership
- Trial oversight
Project Management
One point of contact. With you every step of the way.
- Develop the project plan and timeline
- Select and manage vendors
- Start-up activities and study initiation
- Oversee study conduct and clinical monitoring
- Manage data support teams from protocol development to clinical study report
- Maintain and report pharmacometric deliverables
Clinical Trial Monitoring
- LBPL has skilled and well-trained clinical research associates (CRAs) to ensure the highest quality review of data and effective interaction with study sites.
- Our CRAs will conduct on-site monitoring visits throughout the study to oversee data collection, ensure regulatory compliance, resolve data queries and review source documentation and CRFs.
Study Feasibility
- Acceptability of the study from scientific, regulatory and ethical perspectives.
- Accessibility to specific equipments.
- Expediting of your study.
We at LBPL conduct different types of feasibility
- Study feasibility
- Site or investigator level feasibility
Patient Recruitment
LBPL provides solutions for patient recruitment for clinical trials as detailed below :
- Providing highly qualified referrals that can be converted into randomized patients, boosting your enrollments by as much as 30-50%
- Utilizing our efficient processes and advanced tools rather than adding more sites
- LBPL site relationship managers will work hand-in-hand to maximize patient enrollment and expedite your studies
- LBPL gives you experienced staff and tools needed to keep patients engaged and active so you don’t have to revisit the recruitment phase.
- Provides Patient education materials and notifications written in local languages to help motivate patients to complete your study
Medical writing :
Medical Writing at LBPL includes regulatory and clinical writing services including peer-review publications. We have expertise in developing scientific documents in accordance to the SOPs and customized as per sponsor’s requirements that comply to ICH GCP guidelines.
- Protocol Design & Development
- Clinical Study Report
- Customized as per sponsor’s requirements
- Informed Consent Forms
- Periodic Safety Update Reports
Liveon Biolabs is expert in providing Speciality Preclinical Services. Our scientists carefully evaluate your requirements and take your claims to next level.
Our Speciality Services :
In vivo Pharmacology Models :
Central Nervous System & Behavioural Studies
- Test for Muscle Coordination
- Open Field Test
- Scopolamine Induced Amnesia
- Forced Swim Test
- Elevated Plus Maze Test
- Y Maze Test
- Beam Walk Test
- Rota Rod Test
- Modified Morris Water Maze Test
Respiratory System
- Histamine Induced Bronchospasm
- Histamine Induced Bronchoconstriction
- Bronchospasmolytic Activity
- Citric Acid Inhalation Induced Cough
- Mechanical Stimulation Induced Cough
Gastrointestinal System
- Antidiarrhoeal Activities
- Antiamoebiasis Activities
Pain and Inflammatory Models
- CFA/Carrageenan induced hyperalgesia in rats
- Carrageenan and LPS induced paw edema in rats
- Oxazolone induced ear edema in mice
- Antiinflammatory Study
- Acetic acid induced writhing in mice
- Collagen Induced Arthritis
- Adjuvant Induced Arthritis
- Acute Systematic Anaphylaxi
- Arthus Type Immediate Hypersensitivity
- Delayed Type Hypersensitivity
Nephroprotective Study
- Ethylene Glycol Induced Urolithiasis
- Diurihic Activity (LIPSCHIT-2 Test)
- Gentamycin Induced Nephro-toxicity
- Sodium Oxalate Induced Urolithiasis
Opthalmology
- Anticataract Activity
- Antiglaucomatous Activity
Follow us